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KMID : 1161520180220050299
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Animal Cells and Systems
2018 Volume.22 No. 5 p.299 ~ p.304
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The microRNA-127-3p directly targeting Vamp2 in C2C12 myoblasts
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Li Jie
Wang Gaofu
Jiang Jing
Fu Lin
Zhou Peng
Ren Hangxing
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Abstract
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MicroRNAs (miRNAs) have been reported that can regulate skeletal muscle growth and development. Previously, we demonstrated that miR-127-3p were differently expressed in skeletal muscle and muscle cells. However, the molecular mechanism of miR-127-3p regulation of skeletal myogenesis are not well elucidated. In this study, we transfected miR-127-3p into C2C12 cells, and found miR-127-3p induces myogenesis by targeting Vamp2. Moreover, the regulatory mechanism of Vamp2 in myoblasts proliferation and differentiation was further confirmed. In conclusion, our data providedevidences that miR-127-3p reciprocally regulated myoblasts proliferation and differentiation through directly targeting Vamp2.
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KEYWORD
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Myogenesis, miR-127-3p, Vamp2, C2C12
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